Selected Publications
Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant
Larson JE, Hardy PB, Schomburg NK, Wang X, Kireev D, Rossman KL & Pearce KH. Development of a high-throughput TR-FRET screening assay for a fast-cycling KRAS mutant. SLAS Discovery S2472-5552(22)13713-5. (2022)
Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors
McFall T, Schomburg NK, Rossman KL & Stites EC. Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors. Cell Communication and Signaling 18:179 (2020)
Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-activating Proteins in Basal-like Breast Cancers
Lawson et al. Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers. Cancer Res. 2016;76(13):3826–3837. doi:10.1158/0008-5472.CAN-15-2923
RAS isoforms and mutations in cancer at a glance
Hobbs et al. (2016) RAS isoforms and mutations in cancer at a glance. Journal of cell science. 129(7):1287-92.
Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase
Kim et al. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Mol Cell Biol. 2015;35(1):167–181. doi:10.1128/MCB.00857-14
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
Damoulakis et al. (2014) P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. J. Cell Sci. 127(Pt 11):2589-600.
The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility
Mitin et al. (2013) The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility. PloS one. 8(6):e66260.
Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4
Mitin et al. (2012) Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. PloS ONE. 7(7):e41876.
Release of auto-inhibition of Asef by APC leads to Cdc42 activation and tumor suppression
Mitin et al. (2007). Release of auto-inhibition of Asef by APC leads to Cdc42 activation and tumor suppression. Nat. Struct. Mol. Biol. 9, 814-823.
Auto-inhibition of the Dbl Family protein Tim by an N-terminal helical motif
Yohe et al. (2007). Auto-inhibition of the Dbl Family protein Tim by an N-terminal helical motif. J. Biol. Chem. 282, 13813-23.
GEF means go: turning on Rho GTPases with guanine nucleotide-exchange factors
Rossman et al. (2005). GEF means go: turning on Rho GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell. Biol. 8, 167-80.
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
Rossman et al. (2003). Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation. J. Biol. Chem. 278, 18393-400.
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange
Rossman et al. (2002). A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J. 21, 1315-26.
Crystal Structure of Rac1 in Complex With the Guanine Nucleotide Exchange Region of Tiam1
Worthylake et al. (2000). Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature 408, 682-8.